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Full papers

42. Shiino H.†, Furuta S.†, Kojima R., Kimura K., Endo T., and Tamura Y.* (2020) Phosphatidylserine flux into mitochondria unveiled by organelle-targeted Escherichia coli phosphatidylserine synthase PssA. FEBS J.  doi: 10.1111/febs.15657. Online ahead of print. †Equall contribution

41. Tashiro S., Kakimoto Y., Shinmyo M., Fujimoto S. and Tamura Y.* (2020) Improved Split-GFP Systems for Visualizing Organelle Contact Sites in Yeast and Human Cells. Front. Cell Dev. Biol. 8:571388. doi: 10.3389/fcell.2020.571388

40. Tamura T., Fujisawa A., Tsuchiya M. Shen Y., Nagao K., Kawano S., Tamura Y., Endo T., Umeda M., & Hamachi I.* (2020) Organelle membrane-specific chemical labeling and dynamic imaging in living cells. Nat. Chem. Biol.

39. Shirane M.*, Wada M., Morita K. Hayashi N., Kunimatsu R., Matsumoto Y., Matsuzaki F., Nakatsumi H., Ohta K., Tamura Y., &  Nakayama KI.* (2020) Protrudin and PDZD8 contribute to neuronal integrity by promoting lipid extraction required for endosome maturation. Nat. Commun. 11, 4576.

38. Nakamura, S., Matsui, A., Akabane, S. Tamura, Y., Hatano, Z., Miyano, Y., Omote, H., Kajikawa, M., Maenaka, K., Moriyama, Y., Endo, T., & Oka T.* (2020) The mitochondrial inner membrane protein LETM1 modulates cristae organization through its LETM domain. Commun Biol. 3, 99.

37. Kudo S., Shiino H., Furuta S., Tamura Y.* (2020) Yeast transformation stress, together with loss of Pah1, phosphatidic acid phosphatase, leads to Ty1 retrotransposon insertion into the INO4 gene FASEB J., in press

36.  Watanabe Y., Tamura Y., Kakuta C., Watanabe S., and Endo T.* (2020) Structural basis for inter-organelle phospholipid transport mediated by VAT-1 JBC., in press (doi: 10.1074/jbc.RA119.011019)

35. Matsumoto S., Nakatsukasa K., Kakuta C., Tamura Y., Esaki M., and Endo T. (2019) Msp1 Clears Mistargeted Proteins by Facilitating Their Transfer from Mitochondria to the ER Mol. Cell., 76, 191-205.  (doi: 10.1016/j.molcel.2019.07.006)


34. Wang C., Taki M., Sato Y., Tamura Y., Yaginuma H., Okada Y., and Yamaguchi S. (2019) A photostable fluorescent marker for the superresolution live imaging of the dynamic structure of the mitochondrial cristae PNAS., 116, 15817-15822. (doi: 10.1073/pnas.1905924116)


33. Sakaue H., Shiota T., Ishizaka N., Kawano S., Tamura Y., Tan KS., Imai K., Motono C., Hirokawa T., Taki K., Miyata N., Kuge O., Lithgow T., and Endo T.* (2019) Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly Mol. Cell, 73, 1044–1055


32. Sawasato K., Sato R., Nishikawa H., Iimura N., Kamemoto Y., Fujikawa K., Yamaguchi T., Kuruma Y., Tamura Y., Endo T., Ueda T., Shimamoto K. and Nishiyama K.* (2019) CdsA is involved in biosynthesis of glycolipozyme MPIase essential for membrane protein integration in vivo. Sci. Rep., 9, Article number: 1372


31. Ueda E., Tamura Y., Sakaue H., Kawano S., Kakuta C., Matsumoto S., and Endo T.* (2019) Myristoyl group-aided protein import into the mitochondrial intermembrane space. Sci. Rep., 9, Article number: 1185.

30. Kojima R., Kakimoto Y., Furuta S., Itoh K., Sesaki H., Endo T., and Tamura Y.* (2019) Maintenance of Cardiolipin and Crista Structure Requires Cooperative Functions of Mitochondrial Dynamics and Phospholipid Transport. Cell Rep., 26, 518–528.


29. Tashiro, S. Caaveiro, J. Nakakido, M. Tanabe, A. Nagatoishi, S. Tamura, Y. Matsuda, N. Liu, D. Hoang, Q. and Tsumoto, K. (2018). Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1. ACS. Chem. Biol., 13(9):2783-2793. doi: 10.1021/acschembio.8b00701.


28. Kakimoto, Y. Tashiro, S. Kojima, R. Morozumi, Y. Endo, T. & Tamura, Y. (2018) Visualizing multiple inter-organelle contact sites using the organelle-targeted split-GFP system. Sci. Rep., 8, Article number: 6175. doi:10.1038/s41598-018-24466-0


27. Kawano, S. Tamura, Y. Kojima, R. Bala, S. Asai,  Michel, EA. Kornmann, B. Riezman, I.Riezman, H. Sakae, Y. Okamoto, Y. and Endo T. (2018). Structure–function insights into direct lipid transfer between membranes by Mmm1–Mdm12 of ERMES.
J. Cell. Biol. 217, 959–974. DOI: 10.1083/jcb.201704119.


26. Miwa, K., Kojima, R., Obita, T., Ohkuma, Y., Tamura, Y., and Mizuguchi, M. (2016). Crystal Structure of Human General Transcription Factor TFIIE at Atomic Resolution. J. Mol. Biol. 428, 4258-4266. doi: 10.1016/j.jmb.2016.09.008.


25. Kojima R. Kajiura S. Sesaki H. Endo T. Tamura Y. (2016) Identification of multi-copy suppressors for endoplasmic reticulum-mitochondria tethering proteins in Saccharomyces cerevisiae. FEBS Lett. 590, 3061-70. DOI: 10.1002/1873-3468.12358


24. Arakawa S. Yunoki K. Izawa T. Tamura Y. Nishikawa S and Endo T. (2016) Quality control of nonstop membrane proteins at the ER membrane and in the cytosol. Sci. Rep. 6, Article number: 30795; doi: 10.1038/srep30795


23. Kojima. R. Endo T. and Tamura Y. (2016) A phospholipid transfer function of ER-mitochondria encounter structure revealed in vitro. Sci. Rep. 6, Article number: 30777 doi:10.1038/srep30777


22. Miyata N. Watanabe Y. Tamura Y. Endo T. and Kuge O. (2016) Phosphatidylserine transport by Ups2-Mdm35 for phosphatidylethanolamine synthesis in respiration-active mitochondria. J. Cell Biol. 214, 77-88. doi: 10.1083/jcb.201601082


21. Watanabe, Y., Tamura, Y., Kawano, S., and Endo T. (2015) Structural and mechanistic insights into phospholipid transfer by Ups1–Mdm35 in mitochondria. Nat. Commun. 6, Article number: 7922 doi:10.1038/ncomms8922


20. Koyano F., Okatsu K., Kosako H., Tamura Y., Go E., Kimura M., Kimura Y., Tsuchiya H., Yoshihara H., Hirokawa T., Endo T., Fon EA., Trempe J., Saeki Y., Tanaka K.* and Matsuda N.* (2014) Ubiquitin is phosphorylated by PINK1 to activate Parkin. Nature, 510,162-166  


19. Song, J., Tamura Y., Yoshihisa T. and Endo T.* (2014) A novel import route for an N-anchor mitochondrial outer membrane protein aided by the TIM23 complex (2014) EMBO Rep.,15, 670-677.  


18. Okamoto, H., Miyagawa, A., Shiota, T., Tamura, Y. and Endo, T.* (2014) Intra-molecular disulfide bond of Tim22 maintains integrity of the TIM22 complex in the mitochondrial inner membrane. J. Biol. Chem., 289, 4827-4838.


17. Tamura, Y., Harada, Y., Nishikawa, S., Yamano, K., Kamiya, M., Shiota, T., Kuroda, T., Kuge, O., Sesaki, H., Imai, K., Tomii, K. and Endo, T.* (2013) Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria. Cell Metab., 17, 709-718.  


16. Itoh, K., Tamura, Y., Iijima, M. and Sesaki, H.* (2013) Effects of Fcj1-Mos1 and mitochondrial division on aggregation of mitochondrial DNA nucleoids and organelle morphology. Mol. Biol. Cell, 24, 1842-1851.


15. Tamura Y.*, Onguka O, Itoh K, Endo T, Iijima M, Claypool S.M.*, Sesaki H* (2012) Phosphatidylethanolamine biosynthesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins UPS1P and UPS2P. J. Biol. Chem., 287, 43961-43971. *Co-corresponding authors.  


14. Shiota, T.†, Maruyama, M.†, Miura, M.†, Tamura, Y.†, Yamano, K., Esaki, M. and Endo, T.* (2012) The Tom40 assembly process probed using the attachment of different intramitochondria sorting signals. Mol. Biol. Cell, 23, 3936-3947. †Equal contribution.  


13. Tamura, Y.*, Onguka, O., Aiken Hobbs, A.E., Jensen, R.E., Iijima, M., Claypool, S.M.* and Sesaki, H.* (2012) Role for two conserved intermembrane space proteins, Ups1p and Ups2p, in intra-mitochondrial phospholipid trafficking. J. Biol. Chem., 287, 15205-15218. *Co-corresponding authors.  


12. Trushina, E., Nemutlu, E., Zhang, S., Christensen, T., Camp, J., Mesa, J., Siddiqui, A., Tamura, Y., Sesaki, H., Wengenack, T.M., Dzeja, P.P. and Poduslo, J.F.* (2012) Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease. PLoS One, 7, e32737.


11. Zhang, Z., Wakabayashi, N., Wakabayashi, J., Tamura, Y., Song, W.J., Sereda, S., Clerc, P., Polster, B.M., Aja, S.M., Pletnikov, M.V., Kensler, T.W., Shirihai, O.S., Iijima, M., Hussain, M.A. and Sesaki, H.* (2011) The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Mol. Biol. Cell, 22, 2235-2245.


10. Tamura, Y., Iijima M., and Sesaki H.* (2010) Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation. EMBO J., 29, 2875- 2887.  


9. Harada, Y., Tamura, Y., and Endo. T.* (2010) Identification of yeast Art5 as a multicopy suppressor for the mitochondrial translocator maintenance protein Tam41. Biochem. Biophys. Res. Commun., 392, 228-233.


8. Wakabayashi, J., Zhang, Z., Wakabayashi, N., Tamura, Y., Fukaya, M., Kensler, T. W., Iijima, M., and Sesaki, H.* (2009) The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice.  J. Cell Biol., 186, 805-816. 


7. Tamura, Y., Endo, T., Iijima, M., and Sesaki, H.* (2009) Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria. J. Cell Biol., 185, 1029-1045. 


6. Tamura, Y., Harada, Y., Shiota, T., Yamano, K., Watanabe, K., Yokota, M., Yamamoto, H., Sesaki, H. and Endo, T.* (2009) Tim23-Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import. J. Cell Biol., 184, 129-141.


5. Dunn, C.D., Tamura, Y., Sesaki, H. and Jensen, R.E.* (2008) Mgr3p and Mgr1p are adaptors for the mitochondrial i-AAA protease complex. Mol. Biol. Cell, 19, 5387-5397.  


4. Tamura, Y.†, Harada, Y.†, Yamano, K., Watanabe, K., Ishikawa, D., Ohshima, C., Nishikawa, S., Yamamoto, H. and Endo, T.* (2006) Identification of Tam41 maintaining integrity of the TIM23 protein translocator complex in mitochondria. J. Cell Biol., 174, 631-637. †Equal contribution.  


3. Yamamoto, H., Momose, T., Yatsukawa, Y., Ohshima, C., Ishikawa, D., Sato, T., Tamura, Y., Ohwa, Y. and Endo, T.* (2005) Identification of a novel member of yeast mitochondrial Hsp70-associated motor and chaperone proteins that facilitates protein translocation across the inner membrane. FEBS Lett., 579, 507-511.  


2. Ishikawa, D., Yamamoto, H., Tamura, Y., Moritoh, K. and Endo, T.* (2004) Two novel proteins in the mitochondrial outer membrane mediate beta-barrel protein assembly. J. Cell Biol., 166, 621-627.  


1. Yamamoto, H., Esaki, M., Kanamori, T., Tamura, Y., Nishikawa, S. and Endo, T.* (2002) Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. Cell, 111, 519-528.




8. Tamura Y.* Kawano S. and  Endo T. (2018) Organelle contact zones as sites for lipid transfer, Journal of Biochemistry,165(2), ,115–123 (DOI:  10.1093/jb/mvy088).


7. Endo T. and  Tamura Y. Kawano S. (2018) Phospholipid transfer by ERMES components.  Aging. 10, 139-201 (DOI:  10.18632/aging.101434).


6. Endo T. and  Tamura Y. (2018) News and Views;  Shuttle mission in the mitochondrial intermembrane space.  EMBO J. e98993 (DOI 10.15252/embj.201898993).


5. Tamura Y.* Sesaki H. and Endo T. (2014) Phospholipid transport via mitochondria. Traffic. 15, 933-945.


4. Zhang Q., Tamura Y., Roy M., Adachi Y., Iijima M., Sesaki H.* (2014) Biosynthesis and Roles of Phospholipids in Mitochondrial Fusion, Division and Mitophagy. Cell. Mol. Life Sci. 71, 3767-78.   


3. Tamura, Y.* and Endo, T. (2013) Unveiling the last missing link of the cardiolipin synthetic pathway in mitochondria. Aging, 5, 392-393. (Editorial)   


2. Tamura, Y., Itoh, K. and Sesaki, H.* (2011). SnapShot: Mitochondrial dynamics. Cell 145,1158-1158e1.   


1. Cerveny, K.L., Tamura, Y., Zhang, Z., Jensen, R.E. and Sesaki, H.* (2007) Regulation of mitochondrial fusion and division. Trends Cell Biol., 17, 563-569.

Reviews in Japanese

5. 田村康(2019)ミトコンドリアを介したオルガネラコンタクト,腎臓内科・泌尿器科


4. 田村康,河野慎,遠藤斗志也(2019)ミトコンドリアを介した脂質輸送と代謝,実験医学(増刊)ミトコンドリアと疾患・老化,Vol. 37 No.12, 37-44.


3. 田村康,河野慎,遠藤斗志也(2018)ミトコンドリアと小胞体間のオルガネラコンタクト,生体の科学 第69巻 第6号 2018年 特集:細胞高次機能をつかさどるオルガネラコミュニケーション


2. 田村康,河野慎,遠藤斗志也(2018)ミトコンドリアと小胞体のクロストーク,月刊「細胞」2018年 7月号 オルガネラのバイオロジー 最前線 The leading edge of organelle biology


1. 田村康,遠藤斗志也(2013)Tam41はミトコンドリアにおけるカルジオリピン合成に必要なCDP-ジアシルグリセロール合成酵素である,ライフサイエンス新着論文レビュー(First Author’s)


Book chapters


3. Tamura Y.,* Kojima R., Endo T. (2019) Advanced In Vitro Assay System to Measure Phosphatidylserine and Phosphatidylethanolamine Transport at ER/Mitochondria Interface. In: Drin G. (eds) Intracellular Lipid Transport. Methods in Molecular Biology, vol 1949. Humana Press, New York, NY


2. Tamura Y.* and Endo T. (2017) Role of intra- and inter-mitochondrial membrane contact sites in yeast phospholipid biogenesis, Organelle Contact Sites: From Molecular Mechanism to Disease, Advances in Experimental Medicine and Biology (ed Mitsuo Tagaya, Thomas Simmen), Springer. DOI: 10.1007/978-981-10-4567-7


1. Tamura, Y., Iijima, M., and Sesaki, H. (2009). Mitochondrial dynamics: fusion and division, In The Handbook of Cell Signaling (ed. Ralph Bradshaw and Edward Dennis), Elsevier, Inc.

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